Mechanism of Propolis Affecting Oral Flora Structure and Immune Microenvironment of Oral Mucositis in Patients with Leukemia Undergoing Chemotherapy

To explore the mechanism of effect propolis on oral flora structure and immune microenvironment mucositis in patients with leukemia after chemotherapy. According to principle clinical research guidance antibacterial drugs, curative chemotherapy treatment was judged, bacteriological detection method used detect species, amount composition ratio cavity reverse transcription polymerase chain reaction, enzyme-linked immunoassay western blot were messenger ribonucleic acid expression interleukin 22 tumour necrosis factor alpha mucosa patients, levels chemokines, chemokine (C-X-C motif) ligand 9 10 proteins. After 2 w chemotherapy, incidence increased number neutrophils decreased. Besides, bone marrow hyperplasia aggravated at same time compared control group, group had higher cure rate mucositis, neutrophil recovery time, total bacterial count, expression, Propolis could reduce symptoms mucosal inflammation adjust improve by reducing inflammatory factors.